The Prevalence of Adult Coeliac Disease in the UK is 1%
CD in Northern Ireland 1 in 122 (n=1823)
Johnston SD et al Lancet 1997;350:1370
CD in Sheffield 1 in 100 (n=1200)
Sanders DS et al Eur J Gastroenterol Hepatol 2003;15:407-13
CD in Cambridge 1.2% (n=7550)
West J et al Gut 2003;52:960-5
CD in Bristol 1% (n=5470)
Bingley P et al BMJ 2004;328:322-3
New concepts about coeliac disease
The commonest age for presentation is between the 4th to 6th Decade
For every paediatric case diagnosed there are 9 adult cases
For every adult case diagnosed there are 3 cases still not recognised
People with undiagnosed adult coeliac disease generally have a normal BMI and may even be overweight
Fassano A & Catassi C Gastroenterology 2001;120:636-51
Recognising CD in Gastroenterology
Presentations are numerous and subtle
Dyspepsia/Reflux
(Bardella MT et al Arch Intern Med 2000;160:1489-91)
Endoscopy
(Dickey W et al Am J Gastroenterol 1999;94:2182-6)
IBS
(Sanders DS et al Lancet 2001;358:1504-8
Sanders DS Gastroenterology 2002;123:1408)
NSAP (non-specific abdominal pain)
(Sanders DS et al Ann Surg 2005;242:201-7)
Anaemia (Iron, Vitamin B12 and Folate)
Family history (1st degree relative) ~ 10% risk
Coeliac Disease is diagnosed by showing a flat bowel (villous atrophy) on a biopsy in patients who have positive antibody blood tests (serology) to gluten. These antibodies are called Endomysial antibody or Tissue Translglutaminase antibody.
Coeliac disease in primary care: case finding study
Howard Hin, Graham Bird, Peter Fisher, Nick Mahy, Derek Jewell
Case finding for coeliac disease in primary care using clinical algorithms results in increased detection. So when patient were tested for coeliac disease in primary care using the categories noted on the right hand side, there was a significant diagnostic yield of previously undiagnosed patients who had presented on numerous occasions to their GP’s with non specific symptoms.
Hin H et al BMJ 1999;318:164-7
What’s New?
Point of Care Testing: may ensure early and rapid detection in primary care settings
The Quality of life in patients with coeliac disease is worse than those with ulcerative colitis (Barratt SM et al Eur J Gastroenterol Hepatol 2011)
NICE: Costs per 100,000 population: ‘testing is cost effective from a QUALY perspective’
What drives adherence to a Gluten Free Diet?Factors that were most associated with good adherence to a gluten-free diet were follow-up with an engaged healthcare professional and membership of a coeliac disease advocacy group and this should be strongly encouraged.